<p>The study aimed to estimate the correlation between family functioning and depressive symptoms in high-school adolescents in Santa Marta, Colombia. A cross-sectional study was done which the participation of a sample of high-school students between 13 and 17-year-old. Students completed the family APGAR questionnaire that quantifies adaptation, participation, growth, affectivity, and problem-solving in the family context and the General Wellbeing Index (WHO-5) quantifying depressive symptoms. Spearman (<em>r<sub>s</sub></em>) correlations established the relationship between the APGAR item scores and total WHO-5 score. 1,462 students participated in the study (M = 15.98, SD = 0.82), and 60.33% were females. The correlations between the family APGAR items and depressive symptoms scores were <em>r<sub>s</sub></em> = 0.34 for adaptation, <em>r<sub>s</sub></em> = 0.37 for participation, <em>r<sub>s</sub></em> = 0.33 for growth, <em>r<sub>s</sub></em> = 0.33 affectivity, and <em>r<sub>s</sub></em> = 0.38 problem resolution, all with p-values &lt; 0.01. In conclusion, the APGAR items correlated positively with depressive symptoms. Family functioning should always consider in studies that explore depressive symptoms in high-school students.</p>