<p>The objective of this research was to evaluate the relationship between perfectionism, psychological well-being and dispositional flow in nurses. A quantitative study with descriptive-correlational scope was designed. The sample consisted of 150 nurses (mean age = 41.95, <em>SD</em> = 11.24) who were working in public and private health institutions of Caracas. The variables were measured with self-report instruments. Descriptive statistics and bivariate correlations were used in the analysis of the data. Moderate levels of perfectionism were found, along with high levels of well-being and flow. Perfectionism was positively related to well-being and dispositional flow (<em>p</em> &lt; .01). The results highlight the psychological adjustment of the nursing staff and contradict the prevailing negative view on perfectionism.</p>