<p>A cross-sectional study conducted, involving 2211 adolescents from four public schools. A scale of school safety and psychoactive substance use was applied. The age was 13.6 years. Physical fights on school property were the most reported violent behavior, 44.1% participation in at least one fight in the school year. For school violence, there are many differences in terms of gender, grade, scores and school shift. In substance consumption, 33.6% reported having drunk a glass of alcohol in the last month, 14.3% reported having smoked tobacco cigars and 9.1% of marijuana (p &lt;.05). In substance use, there were only differences by grade, grades and school shift (p &lt;.05), not between sexes. Approximately 3 and 4 out of 10 adolescents, report risk behaviors, the results suggest prevention,  prioritizing vulnerable groups, particularly men with a higher school grade, afternoon shift and low school grades.</p>