<p><strong>Objective</strong>: The pandemic caused by COVID-19 has meant a period of confinement likely to generate population distress. This study evaluates the psychological impact of COVID-19, self-perceived health, coping, and resilience in the general population (n=158) and healthcare professionals (n=78) during the first confinement in Spain (March-April 2020). <strong>Methods</strong>: Cross-sectional online survey study. <strong>Results</strong>: Compared to the general population, healthcare professionals were no more impacted, nor did they express worse self-perceived health. However, they did reveal a lower use of coping strategies based on emotional expression (p=.001), the search for social support (p=.019), or social withdrawal (p=.001). They also tended to show a more resilient profile than the general population (p=.056). Profiles with the greatest emotional impact are usually composed of women (independently of being or not healthcare professionals) who have suffered the loss of a loved one, referring poor health and making greater use of coping strategies of social support, problem-solving, cognitive restructuring, and social withdrawal (explained variance between 20-28%). <strong>Conclusions</strong>: Despite these results, it is recommended not only to monitor the emotional impact of women in the general population who have suffered losses or have reported poor self-perceived health, but also the healthcare community since they have revealed less use of coping strategies during the experience of potentially destabilizing situations such as that created by the COVID-19 and, in the medium-long term, this could be detrimental for their mental health.</p>