<p>The objective of this work is to present the relationship between the characteristics of the depersonalization syndrome and people with gender change. A total sample of 200 people, 100 people with gender change (non-accidental probability) and 100 people was made. Identifying with their biological gender, 50 men and 50 women (accidental probability), the methodology focused on the application of a single psychological test that allows evaluating depersonalization. Among the findings is the significant difference between the samples, giving people with gender change as the most affected, the variable of interest, the relationship between gender change and depersonalization, giving a correlation of .995.</p>