<p><em>Introduction</em>: The purpose of the study was to examine the relationship between depressed mood, level of alcohol use, and suicidal ideation in Puerto Rican adolescents and, more specifically, how good of a predictor of suicidal ideation is depressed mood and level of alcohol use. <em>Methods</em>: Secondary data analyses were conducted with data from Puerto Rico Mental Health and Substance Prevention Administration. The sample consisted of 6,259 participants (3,559 females and 2,700 males) from 130 middle and high schools in Puerto Rico. Logistic regression analyses were conducted with the Statistical Package for Social Sciences (SPSS) program. <em>Results</em>: Depressed mood was a significant predictor of suicidal ideation as expected but the level of alcohol use was found also to be a significant moderator variable for suicidal ideation. <em>Conclusion</em>: These findings highlight the importance of early detection of adolescents with risky behaviors to be clinically treated.</p>
<p><em>Keywords</em>: Depressed mood, alcohol use, suicidal ideation, adolescents, Puerto Rico</p>
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