<p>Marion  Inostroza:<br><br>I believe that you would serve as an excellent reviewer of the manuscript, "Sleep and behavioral disturbances induced by epilepsy: Protective effect of Gabapentin: Sueño y conducta alterados por la epilepsia: Efecto de la Gabapentina," which has been submitted to Revista Interamericana de Psicología/Interamerican Journal of Psychology. The submission's abstract is inserted below, and I hope that you will consider undertaking this important task for us.<br><br>Please log into the journal web site by 2020-11-22 to indicate whether you will undertake the review or not, as well as to access the submission and to record your review and recommendation.<br><br>The review itself is due 2020-12-06.<br><br>Submission URL: <a href='https://journal.sipsych.org/index.php/IJP/reviewer/submission?submissionId=1458&reviewId=943&key=zji7vk' class='submissionReviewUrl-style-class'>https://journal.sipsych.org/index.php/IJP/reviewer/submission?submissionId=1458&reviewId=943&key=zji7vk</a><br><br>Thank you for considering this request.<br><br>Mario Arturo Laborda Rojas<br>Universidad de Chile, Santiago, Chile.<br>mariolaborda@u.uchile.cl<br><br><br><br>"Sleep and behavioral disturbances induced by epilepsy: Protective effect of Gabapentin: Sueño y conducta alterados por la epilepsia: Efecto de la Gabapentina"<br><br>Abstract</p>
<p>Numerous sleep disturbances induced by nocturnal epilepsy have been reported. Gabapentin (GBP) is used as an adjuvant or as a monotherapeutic treatment as it induces significant improvement in patients with partial or secondaryly widespread focal seizures. In experimental animal models of epilepsy with pentilenetetrazole (PTZ), GBP protects against the generated seizures. The objective of this work was to investigate its effectiveness in protecting against motor and sleep disturbances caused by seizures. Polygraphic studies were conducted in male wistar rats, separated into 4 groups. After administration of saline solution, a check record was carried out on each group. Subsequently, one group received 50 mg/kg of PTZ, while the other three groups received 15, 30 or 60 mg/kg GBP, 30 minutes prior to PTZ administration. After administration of PTZ, electrophysiological and behavioral manifestations characterizing seizures were observed. In addition, surveillance states were significantly altered, increasing the amount of wakefulness, while sleep was inhibited over a period of time. The administration of increasing doses of GBP tended to inhibit the presence of abnormal motor behaviors, facilitating the presence of sleep.</p><br/><p>The following message is being delivered on behalf of Revista Interamericana de Psicología/Interamerican Journal of Psychology. ______________________________________</p>
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<div><strong><span class="size">Dr. Fernando Andres Polanco</span></strong></div>
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