<p>A cultural validation of the Interpersonal Reactivity Inventory (IRI) was carried out, translating into Spanish and reviewing its psychometrical properties, evaluating two-factor, four-factor and four-factor + one general-factor models. 386 university students participated in a non-probabilistic sampling (18 - 30 years old, M=20.2; SD=2.6). The reliability of the dimensions was adequate (Cronbach's alpha 0.66 &lt;α &lt;0.78; McDonald's Omega 0.70 &lt;Ω &lt;0.80). Confirmatory Factor Analysis showed good fit to four-factor model and for four-factor + one general-factor model and insufficient in two-factor model. Women showed higher scores in affective dimensions whereas men showed higher scores in cognitive dimensions. IRI 22 items reduced version shows good psychometric properties in young Colombian population.</p>