<p>This study aimed to determine which coping strategies influence psychological well-being of university students in the Dominican Republic during the COVID-19 pandemic. Participants from a private university in Santo Domingo between 18-25 participated (n=135). They completed an online survey with a sociodemographic section, the Psychological Well-being Scale (EBP), and the Coping Orientation to Problems Experienced scale (COPE-48). Six multiple regression analyses with forward selection were conducted to create prediction models for each dimension of psychological well-being with coping strategies' dimensions as independent variables. The models explained 23% to 40% of the psychological well-being variance.&nbsp; A factor analysis classified the coping strategies as (1) positive, exerting a positive influence on well-being, and (2) negative, exerting a negative effect on well-being. The models' positive strategies were: (1) acceptance and personal growth and (2) search for social support. The model's negative strategies were: (1) alcohol or drug use, (2) focus on emotions and vent, (3) denial, and (4) restrain coping. Physical distancing measures and mistrust of health authorities during the pandemic make it difficult to engage in positive coping strategies, allowing people to more easily engage in strategies that negatively affect psychological well-being, increasing the risk of developing clinically relevant symptoms.</p>