<p>The COVID-19 pandemic brought an urgency to develop research not only in treatments, detection and vaccines against the virus but also in other domains of public health, such as quality of life and well-being, since the context changed people’s lives on many levels, including their daily activities and emotions. To verify the possible effects of coronavirus on people’s quality of life, this study investigated this effect with a longitudinal study by data collected before and during the pandemic with a Brazilian sample. The 77 participants with age ranged from 21 to 72 years (<em>M </em>= 44.2; <em>SD </em>= 14.1) and most of them female (70%), responded to the Brazilian version of the WHOQOL-BREF in two moments between 2017 and 2020. The results revealed a significant reduction in the physical and the psychological domains of quality of life, as also for its general evaluation. This shows that the pandemic scenario may affect only specific domains and that public health policies should consider particularities of the current situation for proposing better solutions regarding the improvement of people’s well-being.</p>