<p>In order to determine whether depression, anxiety and concern about COVID-19 predict life satisfaction, a predictive study was conducted in 466 adults in the department of Puno, Peru. The instruments used were the COVID-19 Worry Scale (EPCov-19), the Patient Health Questionnarie-2 (PHQ-2), the Generalized Anxiety Disorder Scale-2 (GAD-2) and the Diener Life Satisfaction Scale (SWLS). Statistical tests such as student t, Pearson r, and multiple linear regression analysis were used. The results indicate significant differences between males and females, when comparing the mean values of depression, anxiety, concern about COVID-19 and life satisfaction, according to sex; also, significant correlations between variables were obtained (p &lt; .05). Regression analysis indicates that the depression variable (β = -.329) significantly predicts life satisfaction. In conclusion, depression as a state of mind of disinterest and displeasure with daily events, significantly predicted life satisfaction in the inhabitants of southern Peru. In addition, anxiety, depression and concern about COVID 19 were higher in women, while life satisfaction was higher in men.</p>