<p>Due to the quarantine implemented by the COVID-19, an important psychological impact has been identified in college students, who are a vulnerable group in relation to the hopelessness analysis. The objective of the present research was to evaluate the levels of hopelessness in 213 Colombian university students, under a quantitative approach of descriptive-comparative scope, with a non-experimental design, in a cross-sectional focus. The Beck Hopelessness Scale was implemented and it was found that 39.9% of the participants had a minimum-normal level; 46.6% mild level; 10.3% intermediate level; and 2.8% high level, founding differences according to gender and social - economic condition. The importance of developing strategies from a comprehensive perspective to care psychosocial consequences associated with the COVID-19 pandemic in students is concluded.</p>