<p>Non-experimental, cross-sectional and correlational study to describe the relationship between grief in the face of the disease, coping strategies and psychopathological symptoms in 14 family caregivers of patients with schizophrenia in Medellín (Colombia), in a non-probabilistic sample for convenience. A medium level of grief was found. High scores in the coping strategies information, positive communication, and social interests; medium-high scores in coercion and resignation; a medium score in social involvement of the patient; and medium-low score in avoidance. Low scores in almost all the psychopathological dimensions, except in obsessions and somatization. Grief is related to the avoidance coping strategy. Between grief and psychopathological symptoms, it was found a relationship with obsessions and compulsions, interpersonal sensitivity, depression, anxiety, and hostility. Finally, between family coping strategies and psychopathological symptoms, it was found a relation of resignation with obsessions and compulsions, and depression.</p>