<p>The present study aimed to understand the experiences and psychological reactions associated with the diagnosis of COVID-19 in the Honduran population. The methodology used was framed within a qualitative approach, with a narrative design. The information was collected through interviews with a total of 35 adult subjects who had been diagnosed with COVID-19. Additionally, as a triangulation point, 5 interviews with medical personnel working on the front line against COVID-19 were included. Among the prevailing matters in the informants' discourse, it is evident that the positive diagnosis of COVID-19 had effects on the daily development of the individual, specifically in relation to labor, economic and academic aspects. In addition, the informants comment on a series of psychological reactions, including feelings of guilt, anxiety, depression, concern for their own health and that of loved ones, deterioration in the quality of sleep, uncertainty, fear, and different attitudes towards seeking psychological help. The importance of support networks is also mentioned, specifically in relation to family, friends, and co-workers. Sometimes the interviewees reported feelings of loneliness and being victims of stigmatization. These results are discussed in light of previous research and their practical implications.</p>