The objective of this research was to compare the profiles of academic self-efficacy of Mexican university students. The total sample was of 1537 participants; 820 women and 717 men, with a mean age of 20.38 years (SD = 1.81) and 20.78 years (SD = 1.94) respectively. The approach taken in the research was framed within a quantitative approach with a survey descriptive design. The results of the multivariate analysis of variance, followed by univariate analyzes of variance, show that women are the ones who show higher levels of self-efficacy in the factors of attention, understanding and excellence. The differences found between men and women regarding their perception of self-efficacy, suggest that when designing any type of intervention that aims to improve perceived self-efficacy will have to take into account the gender variable